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HERO ID
675304
Reference Type
Journal Article
Title
Studies on the toxicity and skin effects of compounds used in the rubber and plastics industries: II. Plasticizers
Author(s)
Mallette, FS; Von Haam, E
Year
1952
Is Peer Reviewed?
Yes
Journal
AMA Archives of Industrial Hygiene and Occupational Medicine
ISSN:
0096-6703
Volume
6
Issue
3
Page Numbers
231-236
Language
English
PMID
14952047
Abstract
The toxicities and skin effects of plasticizers used in rubber and plastic industries were studied in laboratory animals and humans. Twenty five compounds used as plasticizers of synthetic resins were investigated. Rats were administered the compounds by various routes, and mortality was recorded. All animals were necropsied. The compounds were tested for skin irritancy and sensitization in rabbits and humans. Five compounds dioctyl-phthalate (117817), butylbenzyl-phthalate, santicizer-140 (66770443), santicizer-141 (1241947), and flexol-8N8 (61461776) were moderately toxic in doses of 0.6 to 2.4 grams per kilogram (g/kg), generally as a result of intraperitoneal administration. Toxic effects were usually seen in the erythrocytes, blood capillaries, and the central nervous system. The other 20 compounds were essentially nontoxic. All animals supported intraperitoneal injections of 6g/kg or more with no signs of toxic effects. Five compounds showed no skin irritation or sensitization in humans and rabbits: di-2-ethylhexyl-adipate (103231), dibutoxyethyl-diglycol-carbonate, dibutoxyethyl-phthalate (117839), dioctyl-sebacate (122623), and dibutyl-sebacate (109433). Seventeen plasticizers were slight or moderate skin irritants, three were severe skin irritants, and five were moderate sensitizers.
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IRIS
•
BBP (Butyl benzyl phthalate)
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•
Dibutyl sebacate
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