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Citation
Tags
HERO ID
724950
Reference Type
Journal Article
Subtype
Review
Title
The toxicology of perfluorooctanoate
Author(s)
Kennedy, GL; Jr; Butenhoff, JL; Olsen, GW; Connor, JCO; Seacat, AM; Perkins, RG; Biegel, LB; Murphy, , SR; Farrar, DG
Year
2004
Is Peer Reviewed?
Yes
Journal
Critical Reviews in Toxicology
ISSN:
1040-8444
EISSN:
1547-6898
Publisher
Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK
Volume
34
Issue
4
Page Numbers
351-384
Language
English
PMID
15328768
DOI
10.1080/10408440490464705
Web of Science Id
WOS:000222638600002
Abstract
PFOA is a peroxisome proliferator (PPAR agonist) and exerts morphological and biochemical effects characteristic of PPAR agonists. These effects include increased beta-oxidation of fatty acids, increases in several cytochrome P-450 (CYP450)-mediated reactions, and inhibition of the secretion of very low-density lipoproteins and cholesterol from the liver. These effects on lipid metabolism and transport result in a reduction of cholesterol and triglycerides in serum and an accumulation of lipids in the liver. The triad of tumors observed (liver, Leydig cell, and pancreatic acinar-cell) is typical of many PPAR agonists and is believed to involve nongenotoxic mechanisms. The hepatocellular tumors observed in rats are likely to have been the result of the activation of the peroxisome proliferator activated receptor alpha (PPARalpha). The tumors observed in the testis (Leydig-cell) have been hypothesized to be associated with an increased level of serum estradiol in concert with testicular growth factors. The mechanism responsible for the acinar-cell tumors of the pancreas in rats remains the subject of active investigation. The mechanism resulting in the hepatocellular tumors in rats (PPARalpha activation) is not likely to be relevant to humans. Similarly, the proposed mechanism for Leydig-cell tumor formation is of questionable relevance to humans. Acinar tumors of the pancreas are rare in humans, and the relevance of the these tumors, as found in rats, to humans is uncertain. Epidemiological investigations and medical surveillance of occupationally exposed workers have not found consistent associations between PFOA exposure and adverse health effects
Keywords
Acids
Tags
IRIS
•
Trichloroethylene (TCE) (Final, 2011)
PFAS
•
Additional PFAS (formerly XAgency)
Literature Search November 2019
Other Sources
ATSDR
Reference list review of included studies
Screened Studies
Excluded
Exclude (TIAB)
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
PubMed
Not prioritized for screening
Potassium perfluorooctanoate
Sodium perfluorooctanoate
•
PFAS 150
Literature Search August 2019
PubMed
Web of Science
Other sources
ATSDR
Screened Studies
Excluded
Exclude (TIAB)
Ammonium perfluorooctanoate
Perfluorooctanoic acid
•
PFHxS
Background References
•
PFOA and PFOS OW MCLG Approaches
Cited in White Papers
•
R5-MI STSC Request
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