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Citation
Tags
HERO ID
7376801
Reference Type
Journal Article
Subtype
Review
Title
Environmental chemicals, breast cancer progression and drug resistance
Author(s)
Koual, M; Tomkiewicz, C; Cano-Sancho, G; Antignac, JP; Bats, AS; Coumoul, X
Year
2020
Is Peer Reviewed?
1
Journal
Environmental Health
EISSN:
1476-069X
Publisher
BioMed Central Ltd
Location
LONDON
Volume
19
Issue
1
Page Numbers
117
Language
English
PMID
33203443
DOI
10.1186/s12940-020-00670-2
Web of Science Id
WOS:000590235700001
Abstract
Breast cancer (BC) is one of the most common causes of cancer in the world and the second leading cause of cancer deaths among women. Mortality is associated mainly with the development of metastases. Identification of the mechanisms involved in metastasis formation is, therefore, a major public health issue. Among the proposed risk factors, chemical environment and pollution are increasingly suggested to have an effect on the signaling pathways involved in metastatic tumor cells emergence and progression. The purpose of this article is to summarize current knowledge about the role of environmental chemicals in breast cancer progression, metastasis formation and resistance to chemotherapy. Through a scoping review, we highlight the effects of a wide variety of environmental toxicants, including persistent organic pollutants and endocrine disruptors, on invasion mechanisms and metastatic processes in BC. We identified the epithelial-to-mesenchymal transition and cancer-stemness (the stem cell-like phenotype in tumors), two mechanisms suspected of playing key roles in the development of metastases and linked to chemoresistance, as potential targets of contaminants. We discuss then the recently described pro-migratory and pro-invasive Ah receptor signaling pathway and conclude that his role in BC progression is still controversial. In conclusion, although several pertinent pathways for the effects of xenobiotics have been identified, the mechanisms of actions for multiple other molecules remain to be established. The integral role of xenobiotics in the exposome in BC needs to be further explored through additional relevant epidemiological studies that can be extended to molecular mechanisms.
Keywords
Breast cancer; Endocrine disrupting chemicals; Environmental exposure; Environmental pollutants; aryl hydrocarbon receptor; cancer stem cells; drug resistance; Organochlorine pesticides; Perfluoroalkyl acid; Polychlorinated biphenyls
Tags
IRIS
•
PCBs
Supplemental
Litsearches
Litsearch: Aug 2020 - Aug 2021
PubMed
•
PCBs Epi Hazard ID
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