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HERO ID
787096
Reference Type
Journal Article
Title
Protective role of Centella asiatica on lead-induced oxidative stress and suppressed reproductive health in male rats
Author(s)
Sainath, SB; Meena, R; Supriya, Ch; Reddy, KP; Reddy, PS
Year
2011
Is Peer Reviewed?
Yes
Journal
Environmental Toxicology and Pharmacology
ISSN:
1382-6689
EISSN:
1872-7077
Volume
32
Issue
2
Page Numbers
146-154
Language
English
PMID
21843793
DOI
10.1016/j.etap.2011.04.005
Web of Science Id
WOS:000294936700005
Abstract
Centella asiatica has been mentioned in ancient ayurvedic text of the Indian system of medicine for its properties to promote intelligence. The objective of the present study was to investigate the beneficial effects of C. asiatica on lead-induced oxidative stress and suppressed reproductive performance in male rats. Significant decrease in the weights of testes and epididymis were observed in lead treated animals. Exposure to lead acetate significantly increased malondialdehyde levels with a significant decrease in the superoxide dismutase and catalase activities in the liver, brain, kidneys and testes of rats. Epididymal sperm count, viable sperms, motile sperms and HOS-tail coiled sperms decreased significantly in lead-exposed rats. Testicular steroidogenic enzyme activities also decreased significantly in lead-exposed rats. No significant changes in the selected reproductive variables were observed in the plant extract alone treated rats. Whereas, co-administration of aqueous extracts of C. asiatica to lead exposed rats showed a significant increase in the weights of reproductive organs, reduction in lead-induced oxidative stress in the tissues and improvement in selected reproductive parameters over lead-exposed rats indicating the beneficial role of C. asiatica to counteract lead-induced oxidative stress and to restore the suppressed reproduction in male rats.
Keywords
Lead; Oxidative stress; Male reproduction; Sperm; Centella asiatica and rat
Tags
NAAQS
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ISA-Lead (2013 Final Project Page)
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Health Effects
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ISA - Lead (2024 Final Project Page)
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Appendix 8 (Reproductive and Developmental Effects)
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Appendix 8 (Reproductive and Developmental Effects)
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Appendix 8 (Reproductive and Developmental Effects)
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Title-Abstract Screening (SWIFT-AS) - Included
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