US EPA

791209 

Technical Report 

Risk of chronic toxicity associated with exposure to diisononyl phthalate (DINP) in children's product 

U.S. Consumer Product Safety Commission :: CPSC 

1998 

U.S. Consumer Product Safety Commission 

Bethesda, MD 

80 

English 

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has summary 679856 s. Executive summary
has individual parts 1987138 Appendix A: Migration of DINP from polyvinyl chloride (PVC) children's products

See also Executive Summary, PB99-115859. l phthalates are plasticizers that are used in products made from polyvinyl chloride (PVC), including teethers, rattles, and squeeze toys. Because plasticizers are not covalently bound to the PVC polymer, oral exposure can occur when children place PVC products into their mouths. In lifetime feeding studies in the rat and mouse, DINP exposure was toxic to the liver and other organs and increased the incidence of hepatocellular adenoma and carcinoma. In contrast to certain other phthalates such as di-(2-ethylhexyl) phthalate (DEHP), DINP had little or no effect on reproduction or development. The staff measured the migration of DINP from children's products using a laboratory method (impaction) previously used for DEHP. Migration rates did not correlate with the DINP content, manufacturing process, or wall thickness. 

Children; Chronic exposure; Toxicity; Risk assessment; Plasticizers; Phthalates; Polyvinyl chloride; Consumer products; Ingestion(Physiology); Histopathology; Liver diseases; Hepatocellular carcinoma; Liver cell adenoma; Diisononyl phthalate; DINP(Diisononyl phthalate); Dialkyl phthalates 

PB99115867