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815271 
Journal Article 
Long-term lead elimination from plasma and whole blood after poisoning 
Rentschler, G; Broberg, K; Lundh, T; Skerfving, S 
2012 
Yes 
International Archives of Occupational and Environmental Health
ISSN: 0340-0131
EISSN: 1432-1246 
85 
3 
311-316 
English 
21701834 
WOS:000301573400008 
OBJECTIVE: Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate.
METHODS: A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled.
RESULTS: P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower.
CONCLUSION: P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure. 
human; urine; Pb; kinetics; modelling; risk