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81540 
Journal Article 
Prediction of creatinine clearance from serum creatinine 
Cockcroft, DW; Gault, MH 
1976 
Yes 
Nephron
ISSN: 0028-2766
EISSN: 1423-0186 
16 
31-41 
English 
A formula has been developed to predict creatinine clearance (Ccr) from serum creatinine (Scr) in adult males: (see article)(15% less in females). Derivation included the relationship found between age and 24-hour creatinine excretion/kg in 249 patients aged 18-92. Values for Ccr were predicted by this formula and four other methods and the results compared with the means of two 24-hour Ccr's measured in 236 patients. The above formula gave a correlation coefficient between predicted and mean measured Ccr's of 0.83; on average, the difference predicted and mean measured values was no greater than that between paired clearances. Factors for age and body weight must be included for reasonable prediction. 
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