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HERO ID
821663
Reference Type
Journal Article
Title
Age at onset of puberty predicts bone mass in young adulthood
Author(s)
Gilsanz, V; Chalfant, J; Kalkwarf, H; Zemel, B; Lappe, J; Oberfield, S; Shepherd, J; Wren, T; Winer, K
Year
2011
Is Peer Reviewed?
Yes
Journal
Journal of Pediatrics
ISSN:
0022-3476
EISSN:
1097-6833
Publisher
MOSBY-ELSEVIER
Location
NEW YORK
Volume
158
Issue
1
Page Numbers
100-5, 105.e1-2
Language
English
PMID
20797727
DOI
10.1016/j.jpeds.2010.06.054
Web of Science Id
WOS:000285161500013
Abstract
To determine whether the commencement and length of puberty influences dual x-ray absorptiometry (DXA) values of bone mineral content (BMC) and bone mineral density (BMD) in the axial and appendicular skeleton at skeletal maturity.
From the Bone Mineral Density in Childhood Study, we identified children who began puberty and completed sexual and skeletal development and examined whether the timing and length of puberty influence DXA values of BMC and BMD at skeletal maturity.
A total of 78 girls and 85 boys began puberty and completed skeletal maturity; 4.4 ± 0.8 and 4.5 ± 0.8 years later, respectively. Multiple linear regression analyses indicated that the age of onset of puberty was a strong negative predictor of DXA bone measurements at skeletal maturity, independent of bone values at the beginning of puberty, and the length of puberty. This negative relation was observed for all BMC and BMD measurements at all skeletal sites, in both boys and girls (all P < .0001). In contrast, length of puberty had no relation to any measures of bone.
In healthy adolescent males and females, bone mass and bone density at skeletal maturity are inversely related to the timing of puberty.
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