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HERO ID
86297
Reference Type
Journal Article
Title
Omega-3 fatty acid prevents heart rate variability reductions associated with particulate matter
Author(s)
Romieu, I; Tellez-Rojo, MM; Lazo, M; Manzano-Patino Cortez-Lugo, M; Julien, P; Belanger, MC; Hernandez-Avila MHolguin, F
Year
2005
Is Peer Reviewed?
Yes
Journal
American Journal of Respiratory and Critical Care Medicine
ISSN:
1073-449X
EISSN:
1535-4970
Volume
172
Issue
12
Page Numbers
1534-1540
Language
English
PMID
16210665
DOI
10.1164/rccm.200503-372OC
Web of Science Id
WOS:000234019000013
Abstract
#Context: Environmental exposure to particulate matter of 2.5 Ám or less (PM2.5) has been associated with changes in heart rate variability (HRV).
Objective: To evaluate the effect of supplementation with omega-3 polyunsaturated fatty acids on the reduction of HRV associated with PM2.5 exposure.
Design: Randomized double-blind trial.
Setting: Mexico City, Mexico.
Participants: 50 nursing home residents older than 60 yr.
Intervention: Randomization to either 2 g/d of fish oil versus 2 g/d of soy oil as the control, with 6 mo follow-up (1-mo presupplementation and 5-mo supplementation) or repeated HRV measurements. PM2.5 was monitored indoors and outdoors.
Main Outcome Measure: The association between HRV and 1 SD change in PM2.5 (8 Ág/m3).
Results: In the group receiving fish oil, the reduction in HRV-high-frequency log10-transformed associated with a 1-SD change in PM2.5 was -54% (95% confidence interval, -72, -24) in the presupplementation phase, and only -7% (95% confidence interval, -20,+7) in the supplementation phase (p < 0.01 for the effect of supplementation), with changes in other HRV parameters also being significantly less pronounced during supplementation. Small decreases in PM2.5-associated reductions in HRV parameters also occurred in the group receiving soy oil, but these were not significant. Fish oil supplementation was significantly better in preventing the reduction in percentage of successive normal RR intervals differing by more than 50 ms (p = 0.03) and the root square of the mean of the sum of the squares of differences between adjacent intervals (p = 0.05) than soy oil supplementation.
Interpretation: Supplementation with 2 g/d of fish oil prevented HRV decline related to PM2.5 exposure in the study population.
Keywords
elderly; heart rate variability; Mexico; omega-3 polyunsaturated fatty acids; PM2.5
Tags
•
ISA-PM (2009 Final Project Page)
2009 Final
•
ISA-PM (2019)
1st Draft
Chapter 12
In Scope
At-risk
Final ISA
Chapter 12
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