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Journal Article 
Effect of acute and chronic exposure of sodium arsenite (Na3AsO3) on total protein, albumin, and globulin in serum of Oryctolagus cuniculus L 
Tripathi, S; Kumar, A 
Toxicological and Environmental Chemistry
ISSN: 0277-2248
EISSN: 1029-0486 
Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK 
2 (Feb 2011) 
Arsenic is a semi-metallic poison known since ancient times. Geber, an Arab alchemist of eighth century produced arsenious oxide from naturally occurring ore found in lead and iron mining and thus one of the most cruel, deadly and widely administered poisons during the medieval history was made available to the humanity. In the modern times, the nature of arsenic threat has changed. Instead of an acute poison used as insecticide, rodenticide or homicide/suicidal purpose it has become a chronic poison mobilized by natural or anthropogenic reasons. In the present article the effect of acute and chronic arsenic exposure in the form of sodium arsenite (Na3AsO3) were studied on total protein, albumin, and globulin in the serum of Oryctolagus cuniculus L. Two sublethal concentrations of sodium arsenite (0.12 and 0.25 mg kg-1 bw) were administered to test animals for 3, 7, or 15 days to determine acute toxicity and for 6 months at an interval of 15 days to measure chronic toxicity. Total protein, albumin, and globulin in serum were determined after each exposure and compared with control. Following acute or chronic intoxication, total protein, albumin, and globulin levels were decreased. 
Mining; Chronic intoxication; Rodenticides; Chronic exposure; Insecticides; oxides; Oryctolagus cuniculus; Iron; Chronic toxicity; Acute toxicity; Arsenic; Albumin; Globulins; Sodium arsenite 
• Arsenic Hazard ID
     1. Initial Lit Search
     4. Considered through Oct 2015
     6. Cluster Filter through Oct 2015
• Arsenic (Inorganic)
     1. Literature
          Web of Science
     4. Adverse Outcome Pathways/Networks Screening
          Excluded/Not relevant
               Title/Abstract screening
• Arsenic MOA
     1. MOA Literature Screening
          MOA Cluster
     3. Excluded
          Other not relevant
               Dragon Screened