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HERO ID
1015659
Reference Type
Journal Article
Title
Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta
Author(s)
Ma, Y; Niu, R; Sun, Z; Wang, J; Luo, G; Zhang, J; Wang, J
Year
2012
Is Peer Reviewed?
Yes
Journal
Archives of Toxicology
ISSN:
0340-5761
EISSN:
1432-0738
Volume
86
Issue
6
Page Numbers
849-856
Language
English
PMID
22422340
DOI
10.1007/s00204-012-0803-9
Web of Science Id
WOS:000304875000004
Abstract
Epidemiological and experimental studies have demonstrated the atherogenic effects of environmental toxicant arsenic and fluoride. Inflammatory mechanism plays an important role in the pathogenesis of atherosclerosis. The aim of the present study is to determine the effect of chronic exposure to arsenic and fluoride alone or combined on inflammatory response in rabbit aorta. We analyzed the expression of genes involved in leukocyte adhesion [P-selectin (P-sel) and vascular cell adhesion molecule-1(VCAM-1)], recruitment and transendothelial migration of leukocyte [interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1)] and those involved in pro-inflammatory cytokines [interleukin-6 (IL-6)]. We found that fluoride and arsenic alone or combined increased the expression of VCAM-1, P-sel, MCP-1, IL-8, and IL-6 at the RNA and protein levels. The gene expressions of inflammatory-related molecules were attenuated when co-exposure to the two toxicants compared with just one of them. We also examined the lipid profile of rabbits exposed to fluoride and (or) arsenic. The results showed that fluoride slightly increased the serum lipids but arsenic decreased serum triglyceride. We showed that inflammatory responses but not lipid metabolic disorder may play a crucial role in the mechanism of the cardiovascular toxicity of arsenic and fluoride.
Keywords
Inflammatory responses; Atherosclerosis; Arsenic; Fluoride
Tags
•
Arsenic Hazard ID
1. Initial Lit Search
PubMed
WOS
ToxNet
WOS
Considered New
2. Lit Search Updates through Oct 2015
WOS
Considered
4. Considered through Oct 2015
5. Additions through Oct 2015
6. Cluster Filter through Oct 2015
7. Other Studies through Oct 2015
MOA
iAs MOA Literature Categorization
Immune
Susceptibility Category
Coexposure
Health Effect Category
Cardiovascular disease
Hematology, Hematopoietic System
Immune System & Lymphatic effects
•
Arsenic (Inorganic)
1. Literature
PubMed
Toxline, TSCATS, & DART
Web of Science
Lit search updates through Oct 2015
3. Hazard ID Screening
Other potentially supporting studies
4. Adverse Outcome Pathways/Networks Screening
Relevant
5. Susceptibility Screening
Relevant
Animal
•
Arsenic MOA
4. Adverse Outcome Pathways
Immune mechanisms
Vascular mechanisms
5. Health Effect
Cardiovascular disease
Immune System and Lymphatic Effects
1. MOA Literature Screening
Health Effect Screening
MOA Cluster
•
Arsenic Susceptibility
4. Susceptibility and Lifestages
Coexposure
5. Health Effect
Cardiovascular disease
Hematology, Hematopoietic System
Immune System and Lymphatic Effects
1. Susceptibility Literature Screening
Keyword Search
Life Stages Citation Mapping
20%-25%
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