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Citation
Tags
HERO ID
1015673
Reference Type
Journal Article
Title
ArxA, a new clade of arsenite oxidase within the DMSO reductase family of molybdenum oxidoreductases
Author(s)
Zargar, K; Conrad, A; Bernick, DL; Lowe, TM; Stolc, V; Hoeft, S; Oremland, RS; Stolz, J; Saltikov, CW
Year
2012
Is Peer Reviewed?
Yes
Journal
Environmental Microbiology
ISSN:
1462-2912
EISSN:
1462-2920
Volume
14
Issue
7
Page Numbers
1635-1645
Language
English
PMID
22404962
DOI
10.1111/j.1462-2920.2012.02722.x
Web of Science Id
WOS:000305904500004
Abstract
Arsenotrophy, growth coupled to autotrophic arsenite oxidation or arsenate respiratory reduction, occurs only in the prokaryotic domain of life. The enzymes responsible for arsenotrophy belong to distinct clades within the DMSO reductase family of molybdenum-containing oxidoreductases: specifically arsenate respiratory reductase, ArrA, and arsenite oxidase, AioA (formerly referred to as AroA and AoxB). A new arsenite oxidase clade, ArxA, represented by the haloalkaliphilic bacterium Alkalilimnicola ehrlichii strain MLHE-1 was also identified in the photosynthetic purple sulfur bacterium Ectothiorhodospira sp. strain PHS-1. A draft genome sequence of PHS-1 was completed and an arx operon similar to MLHE-1 was identified. Gene expression studies showed that arxA was strongly induced with arsenite. Microbial ecology investigation led to the identification of additional arxA-like sequences in Mono Lake and Hot Creek sediments, both arsenic-rich environments in California. Phylogenetic analyses placed these sequences as distinct members of the ArxA clade of arsenite oxidases. ArxA-like sequences were also identified in metagenome sequences of several alkaline microbial mat environments of Yellowstone National Park hot springs. These results suggest that ArxA-type arsenite oxidases appear to be widely distributed in the environment presenting an opportunity for further investigations of the contribution of Arx-dependent arsenotrophy to the arsenic biogeochemical cycle.
Tags
IRIS
•
Arsenic Hazard ID
1. Initial Lit Search
PubMed
WOS
ToxNet
WOS
Considered New
2. Lit Search Updates through Oct 2015
WOS
Considered
4. Considered through Oct 2015
6. Cluster Filter through Oct 2015
7. Other Studies through Oct 2015
Other
•
Arsenic (Inorganic)
1. Literature
PubMed
Toxline, TSCATS, & DART
Web of Science
Lit search updates through Oct 2015
3. Hazard ID Screening
Other potentially supporting studies
5. Susceptibility Screening
Excluded/Not relevant
•
Arsenic Susceptibility
1. Susceptibility Literature Screening
Keyword Search
2. Excluded
Not Relevant
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