US EPA

1015752 

Journal Article 

GSTO and AS3MT genetic polymorphisms and differences in urinary arsenic concentrations among residents in Bangladesh 

Rodrigues, EG; Kile, M; Hoffman, E; Quamruzzaman, Q; Rahman, M; Mahiuddin, G; Hsueh, Y; Christiani, DC 

2012 

Yes 

Biomarkers
ISSN: 1354-750X
EISSN: 1366-5804 

17 

3 

240-247 

English 

22339537 

10.3109/1354750X.2012.658863 

WOS:000303326200007 

We determined whether single nucleotide polymorphisms (SNPs) in the glutathione S-transferase omega (GSTO) and arsenic(III)methyltransferase (AS3MT) genes were associated with concentrations of urinary arsenic metabolites among 900 individuals without skin lesions in Bangladesh. Four SNPs were assessed in these genes. A pathway analysis evaluated the association between urinary arsenic metabolites and SNPs. GSTO1 rs4925 homozygous wild type was significantly associated with higher monomethylarsonic acid (MMA) and dimethylarsinic acid urinary concentrations, whereas wild-type AS3MT rs11191439 had significantly lower levels of As(III) and MMA. Genetic polymorphisms GSTO and As3MT modify arsenic metabolism as evidenced by altered urinary arsenic excretion. 

Pathway analysis; arsenic metabolism; drinking water