Health & Environmental Research Online (HERO)


Print Feedback Export to File
1134636 
Journal Article 
Studies on bronchodilatory effect of Lepidium sativum against allergen induced bronchospasm in guinea pigs 
Mali, RG; Mahajan, SG; Mehta, AA 
2008 
1 
Pharmacognosy Magazine
ISSN: 0973-1296 
4 
15 
189-+ 
English 
The ethanolic extract of seeds of Lepidium sativum and its various fractions were tested for their bronchodilatory effect against histamine and acetylcholine induced acute bronchospasm in guinea pigs. The ethanolic extract and its all the fractions viz. ethyl acetate, n-butanol and methanol exhibited significant protection against bronchospasm induced by histamine and acetylcholine. However, significant ( p<0.001) protection was exhibited by n-butanol fraction which was comparable with that of Ketotifen (1 mg/ kg) and Atropine sulphate (2 mg/kg) included as reference standard in the study. Thus the results of our study suggest that, the plant L. sativum has bronchodilatory activity. 
Lepidium sativum; Bronchodilatory activity; Histamine; Acetylcholine 
IRIS
• n-Butanol
     Database searches
          WOS
     Source – January 2013 (private)
          WOS - 1/2013
          Merged reference set - 1/2013
     Excluded (not pertinent)
          Not chemical specific
• Methanol (Non-Cancer)
     Search 2012
          WOS