US EPA

1290872 

Journal Article 

Review 

Perfluoroalkyl acids: a review of monitoring and toxicological findings 

Lau, C; Anitole, K; Hodes, C; Lai, D; Pfahles-Hutchens, A; Seed, J 

2007 

1 

Toxicological Sciences
ISSN: 1096-6080
EISSN: 1096-0929 

99 

2 

366-394 

English 

17519394 

10.1093/toxsci/kfm128 

WOS:000249885900002 

In recent years, human and wildlife monitoring studies have identified perfluoroalkyl acids (PFAA) worldwide. This has led to efforts to better understand the hazards that may be inherent in these compounds, as well as the global distribution of the PFAAs. Much attention has focused on understanding the toxicology of the two most widely known PFAAs, perfluorooctanoic acid, and perfluorooctane sulfate. More recently, research was extended to other PFAAs. There has been substantial progress in understanding additional aspects of the toxicology of these compounds, particularly related to the developmental toxicity, immunotoxicity, hepatotoxicity, and the potential modes of action. This review provides an overview of the recent advances in the toxicology and mode of action for PFAAs, and of the monitoring data now available for the environment, wildlife, and humans. Several avenues of research are proposed that would further our understanding of this class of compounds. 

Pollution Abstracts; Toxicology Abstracts; Immunotoxicity; perfluorooctanoic acid; Sulfates; Reviews; Wildlife; hepatotoxicity; Sulfate; X 24350:Industrial Chemicals; P 6000:TOXICOLOGY AND HEALTH