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1332882 
Journal Article 
Development and evaluation of acrylic strips of metronidazole for the therapy of periodontal disease 
Sridevi, S; Babu, RJ; Mittal, N; Kumar, DS; Pandit, JK 
1995 
Yes 
Die Pharmazie
ISSN: 0031-7144 
IPA/95/1085212 
50 
2 
153-154 
English 
7700972 
IPA COPYRIGHT: ASHP Metronidazole-loaded strips fabricated from poly(methyl methacrylate) alone and in combination with ethylcellulose and dibutyl phthalate as plasticizers were developed for the local therapy of periodontitis and evaluated both in vivo and in vitro. All formulations had the required tensile strength to ensure their intactness during patient evaluation. A clear effect of the addition of ethylcellulose was observed, but increasing the ethylcellulose proportion did not substantially alter the amount of drug released in 5 days. The desired release rate was achieved by incorporating the drug in a combination of poly(methyl methacrylate) and ethylcellulose. Clinical evaluation in patients showed that the strips were well tolerated and the clinical indices showed improvement. 
Metronidazole; periodontitis; therapy; Ethylcellulose; plasticizers; metronidazole strips; Dibutyl phthalate; Poly(methyl methacrylate); topical preparations; Anti-infective agents; periodontitis therapy; metronidazole(Anti-infective agents; Release; topical strips; Tensile strength; Toxicity; HUMAN 
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