Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
1337462
Reference Type
Journal Article
Title
[Establishment of a mouse model of ovarian oxidative stress]
Author(s)
Wang, XN; Zhang, CJ; Zhang, Y; Ru, X; Gong, QQ
Year
2012
Is Peer Reviewed?
0
Journal
Nan Fang Yi Ke Da Xue Xue Bao / Journal of Southern Medical University
ISSN:
1673-4254
EISSN:
2663-0842
Volume
32
Issue
11
Page Numbers
1643-1645
Language
chi
PMID
23174595
Abstract
OBJECTIVE:
To evaluate the feasibility of establishing a mouse model of ovarian oxidative stress by intraperitoneal injections of arsenic sodium.
METHODS:
Twenty adult female Kunming mice were randomized equally into the normal control group and ovarian oxidative stress model group for intraperitoneal injections of 0.5 ml distilled water and 8 mg/kg arsenic sodium solution every other day, respectively. After 8 injections, the mice were sacrificed for histological observation of the ovarian sections and enzyme-linked immunosorbent assay (ELISA) of serum estradiol (E(2)) and pregnendione (P) levels ande contents of reactive oxygen species (ROS) , malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the ovary homogenate.
RESULTS:
Numerous atretic follicles were found in the ovaries of mice in the model group with obviously reduced growing follicles. Compared with those in the normal control group, the contents of ROS and MDA increased and SOD and GSH-Px levels in the ovarian homogenate decreased significantly in the model group (P<0.05).
CONCLUSION:
A mouse model of ovarian oxidative stress can be established by intraperitoneal injections of arsenic sodium.
Tags
IRIS
•
Arsenic Hazard ID
1. Initial Lit Search
PubMed
3. Initial Filter through Oct 2015
Non-English
Non Peer-Reviewed
•
Arsenic (Inorganic)
1. Literature
PubMed
2. Initial Filter
Non peer-reviewed
Non English
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity