The history and epidemiology of dermatoses were discussed in relation to occupational exposures to hazardous substances or job stressors. Descriptions were provided for the structure and function of the skin as well as clinical aspects of the following: contact dermatitis, chemical burns, solvents, soaps, fiberglass, vegetation, metals and metallic salts, rubber products, pesticides, plastics, organic dyes, and photodermatitis. Also discussed are pigmentary disorders including toxic vitiligo, postinflammatory changes, discolorations and stains; environmental acne, oil acne, chloracne; vascular reactions including urticaria, flushing reactions; connective tissue disorders including vibration white finger, collagen vascular disease; peripheral neuropathy; neoplasms including radiation, polycyclic aromatic hydrocarbons, arsenicals, trauma; infections and infestations including bacteria, mycobacteria, viruses, fungi, parasites; disorders of hair and nails; climatic disorders; establishing the diagnosis; and prevention. The author concludes that most causal relationships illustrated between a skin disease and work exposure are acceptable to workers' compensation boards. Use of the term substantial aggravation is clarified from a diagnostic standpoint.