PESTAB Toxicological studies on herbicides and clinical observations concerning acute, subacuye, and chronic poisonings with herbicides are surveyed. Irritation of skin and mucosa, headache, asthenia, emesis, alterations of the liver, cardiovascular system and the lungs, muscular hypotonia, anorexia, diarrhea, hypothermia, proteinuria, and paralysis of the extremities were observed due to acute poisoning with high doses of dichlorophenoxyacetic acid and trichlorophenoxyacetic acid derived herbicides. Paraquat caused dyspnea, anorexia, intensified mucus secretion, adynamia, hyperemia of internal organs, and sometimes hydrothorax and blood clotting. Nervous system damage, hemorrhage, headache, asthenia, nausea, catarrhal or purulent inflammation of the mucosa, bronchitis, pneumonia, epistaxis, cardiovascular insufficiency, and pulmonary edema are the basic symptoms of poisoning with trivalent arsenic compounds. Tributylphosphate and tributylthiophosphate inhibit cholinesterase activity, irritate the mucosa, and damage the parenchymatous organs. Intensification of oxidative processes, hyperthermia, and damages to the vascular system and parenchymatous organs were noted in dinitrophenol and dinitrocresol poisoning. Serous inflammation of the mucosa, tracheobronchitis, leukocytosis, anemia, degeneration of the parenchymatous organs, and toxic encephalopathy were observed in chronic and acute poisonings with the contact poison endothall.
