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HERO ID
1404905
Reference Type
Journal Article
Subtype
Review
Title
Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes
Author(s)
Miller, MD; Crofton, KM; Rice, DC; Zoeller, RT
Year
2009
Is Peer Reviewed?
Yes
Journal
Environmental Health Perspectives
ISSN:
0091-6765
EISSN:
1552-9924
Publisher
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
Location
RES TRIANGLE PK
Volume
117
Issue
7
Page Numbers
1033-1041
Language
English
PMID
19654909
DOI
10.1289/ehp.0800247
Web of Science Id
WOS:000267621200019
URL
http://
://WOS:000267621200019
Exit
Abstract
BACKGROUND:
There is increasing evidence in humans and in experimental animals for a relationship between exposure to specific environmental chemicals and perturbations in levels of critically important thyroid hormones (THs). Identification and proper interpretation of these relationships are required for accurate assessment of risk to public health.
OBJECTIVES:
We review the role of TH in nervous system development and specific outcomes in adults, the impact of xenobiotics on thyroid signaling, the relationship between adverse outcomes of thyroid disruption and upstream causal biomarkers, and the societal implications of perturbations in thyroid signaling by xenobiotic chemicals.
DATA SOURCES:
We drew on an extensive body of epidemiologic, toxicologic, and mechanistic studies.
DATA SYNTHESIS:
THs are critical for normal nervous system development, and decreased maternal TH levels are associated with adverse neuropsychological development in children. In adult humans, increased thyroid-stimulating hormone is associated with increased blood pressure and poorer blood lipid profiles, both risk factors for cardiovascular disease and death. These effects of thyroid suppression are observed even within the "normal" range for the population. Environmental chemicals may affect thyroid homeostasis by a number of mechanisms, and multiple chemicals have been identified that interfere with thyroid function by each of the identified mechanisms.
CONCLUSIONS:
Individuals are potentially vulnerable to adverse effects as a consequence of exposure to thyroid-disrupting chemicals. Any degree of thyroid disruption that affects TH levels on a population basis should be considered a biomarker of adverse outcomes, which may have important societal outcomes.
Keywords
children's health; endocrine disruption; hazard identification; risk assessment; science policy; thyroid hormone; toxicologic assessments
Tags
IRIS
•
Hexabromocyclododecane (HBCD)
Guidance/contextual references added during assessment development
•
PCBs
Litsearches
Initial Filter
Reviews
LitSearch August 2015
WoS
Targeted review search
Source
OPPT REs
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_C. Engineering
Data screening total
Screening: Excluded
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_F. Human Health
Total – title/abstract screening
Off topic
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