Detection of human papillomavirus genotypes associated with mucopurulent cervicitis and cervical cancer in Changchun, China
Liu, W; Wu, EQ; Yu, XH; Feng, LH; Jiang, CL; Zha, X; Kong, W
| HERO ID | 1508720 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Detection of human papillomavirus genotypes associated with mucopurulent cervicitis and cervical cancer in Changchun, China |
| Authors | Liu, W; Wu, EQ; Yu, XH; Feng, LH; Jiang, CL; Zha, X; Kong, W |
| Journal | International Journal of Gynecology and Obstetrics |
| Volume | 120 |
| Issue | 2 |
| Page Numbers | 124-126 |
| Abstract | <strong>OBJECTIVE: </strong>To determine the prevalence and genotype distribution of human papillomavirus (HPV) infection among Chinese patients with mucopurulent cervicitis (MPC) or cervical cancer (CC).<br /><br /><strong>METHODS: </strong>In total, 191 cases of CC (n=66), acute MPC (n=84), and healthy cervix controls (n=41) were initially included; samples were collected between May 21, 2008, and October 9, 2011. Cervical specimens were screened for HPV using a nested polymerase chain reaction assay and DNA sequencing.<br /><br /><strong>RESULTS: </strong>Overall prevalence of HPV infection was 20.0% in the control group, 53.3% in the MPC group, and 93.8% in the CC group. The predominant genotype detected in all 3 groups was the oncogenic variant HPV 16 (87.7%, 18.7%, and 10.0% in the CC, MPC and control specimens, respectively). The second most frequent genotype among patients with MPC was HPV 58. This variant is also oncogenic and was detected at a higher rate in the MPC group (9.3%) than in the control (2.5%) and CC (1.5%) groups.<br /><br /><strong>CONCLUSION: </strong>Infection with HPV was prevalent among Chinese women with MPC or CC. Furthermore, the high prevalence of oncogenic genotypes observed among HPV-positive patients with MPC suggests that this group is at increased risk of developing CC. |
| Doi | 10.1016/j.ijgo.2012.07.032 |
| Pmid | 23245674 |
| Wosid | WOS:000314433400004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics ISSN: 1879-3479 |
| Is Public | Yes |
| Language Text | English |