The hallmarks of cancer | Health & Environmental Research Online (HERO) | US EPA

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Citation
Tags

HERO ID

188413

Reference Type

Journal Article

Subtype

Review

Title

The hallmarks of cancer

Author(s)

Hanahan, D; Weinberg, RA

Year

2000

Is Peer Reviewed?

Yes

Journal

Cell
ISSN: 0092-8674
EISSN: 1097-4172

Volume

100

Issue

1

Page Numbers

57-70

Language

English

PMID

10647931

DOI

10.1016/S0092-8674(00)81683-9

Web of Science Id

WOS:000084722600005

URL

http://linkinghub.elsevier.com/retrieve/pii/S0092867400816839
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Abstract

After a quarter century of rapid advances, cancer research has generated a rich and complex body of knowledge, revealing cancer to be a disease involving dynamic changes in the genome. The foundation has been set in the discovery of mutations that produce oncogenes with dominant gain of function and tumor suppressor genes with recessive loss of function; both classes of cancer genes have been identified through their alteration in human and animal cancer cells and by their elicitation of cancer phenotypes in experimental models.

Tags

• Chromium VI
     Considered
          Excluded
               Other Not Pertinent
• Cobalt
• Formaldehyde [archived]
     UR Cancer MOA
          Cited
     Retroactive RIS import
          Pre2013
               Formaldehyde IRIS 2011
                    Old references
• IRIS Formaldehyde (Inhalation) [Final 2024]
     Literature Indexing
          Other sources and cited references
     Literature Identification
• Tetrachloroethylene (Perc) (Final, 2012)
     Hazard
          Liver
• Trichloroethylene (TCE) (Final, 2011)
     All References
     Liver Issues
NAAQS
• ISA-PM (2019)
OPPT REs
• OPPT_Perchloroethylene (Perc)_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Perchloroethylene (Perc)_F. Human Health
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_C. Engineering
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_D. Exposure
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_E. Fate
     Total – title/abstract screening
          Off topic
• OPPT_Trichloroethylene (TCE)_F. Human Health
     Total – title/abstract screening
          Off topic