Induction of aryl hydrocarbon hydroxylase and carbon monoxide-binding hemoproteins in mouse epidermis by tobacco carcinogens | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2136229

Reference Type

Journal Article

Title

Induction of aryl hydrocarbon hydroxylase and carbon monoxide-binding hemoproteins in mouse epidermis by tobacco carcinogens

Author(s)

Norred, WP; Akin, FJ

Year

1976

Is Peer Reviewed?

Yes

Journal

Biochemical Pharmacology
ISSN: 0006-2952
EISSN: 1873-2968

Volume

Issue

Page Numbers

732-734

Language

English

PMID

179556

DOI

10.1016/0006-2952(76)90254-9

Web of Science Id

WOS:A1976BK55200022

Abstract

The involvement of cytochrome P-450 in skin aryl hydrocarbon hydroxylase (AHH) activity was previously suggested by inhibition of benzo(a)pyrene hydroxylation by human foreskin in a CO atmosphere. The appearance of a CO binding component in rat skin microsomes after AHH induction with polychlorinated biphenyls was shown, and cytochrome P-448 induction was seen in mouse skin after administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Induction of skin AHH by benzanthracene or cigarette smoke condensate (CSC) fraction 20 was accompanied by increased CO binding hemoprotein. A relatively small increase in this component was associated with a large increase in AHH activity.