US EPA

2172957 

Journal Article 

Behavioral effects of PCBs in mice 

Fanini, D; Palumbo, G; Giorgi, R; Pantaleoni, G 

1990 

Yes 

Behavioural Pharmacology
ISSN: 0955-8810
EISSN: 1473-5849 

1 

6 

505-510 

English 

11175436 

has comment/response 5092212 [Email to Laura Carlson regarding study quality evaluation for Fanini et al. 1990]

A single i.p. administration to mice of Fenclor 54 (PCB) resulted in various behavioral deficits. PCB significantly reduced locomotor activity and exploratory behavior at dosages of 150 and 300 mg/kg. Dose dependent increased latencies were also found at the same dosages in the "traction test" while in the rota rod test the dosage of 300 mg/kg of PCB only caused a significant increase in mean number of falls off the rod. Furthermore daily dietary administration of PCB (1, 10, 100 ppm) to male mice during a 21-day isolation period was inversely proportional to the amount of aggressive behavior shown, and directly proportional to the amount of non-social behavior ("indifference"). This supports former findings reporting anti-androgenic like effects of PCBs.