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2185502 
Journal Article 
Polychlorinated-biphenyls (pcbs) depress allogeneic natural cytotoxicity by earthworm celomocytes 
Suzuki, MM; Cooper, EL; Eyambe, GS; Goven, AJ; Fitzpatrick, LC; Venables, BJ 
1995 
Yes 
Environmental Toxicology and Chemistry
ISSN: 0730-7268
EISSN: 1552-8618 
BIOSIS/95/36309 
14 
10 
1697-1700 
English 
WOS:A1995RV70900009 
Coelomocytes of the earthworm Lumbricus terretris caused significant spontaneous allogeneic cytotoxicity in a 24-h trypan blue assay, but not in an assay using lactate dehydrogenase (LDH) release. Allogeneic cytotoxicity assays using cells from worms exposed to polychlorinated biphenyls (PCBs) suggest that PCBs can suppress a natural killing (NK-like) reaction. The implications of this work are twofold: understanding the evolution of natural killing (NK-like) activity and providing preliminary information on how spontaneous killing, a component of cellular immunity, may be compromised by pollutants. 
EARTHWORM; PCB; ALLOGENEIC; NATURAL CYTOTOXICITY 
IRIS
• PCBs
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