US EPA

2193679 

Technical Report 

MUTAGENICITY, ACUTE TOXICITY, AND BIOACCUMULATION POTENTIAL OF SIX CHLORINATED STYRENES 

Tarkpea, M; Hagen, I; Carlberg, GE; Kolsaker, P; Storflor, H 

1985 

Yes 

Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 

Springer-Verlag 

EMICBACK/61950 

525 

4 

525-530 

English 

10.1007/BF01636549 

https://www.scopus.com/inward/record.uri?eid=2-s2.0-34250117187&doi=10.1007%2fBF01636549&partnerID=40&md5=124ae978029d45493427cc43a556850a
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The mutagenicity and acute toxicity of six chlorinated styrenes were investigated. The potential for bioaccumulation was also evaluated. Nitocra-spinipes (Nitocra) were exposed to pentachlorostyrene (14992815), trans-hexachlorostyrene (tHCS), trans-heptachlorostyrene (29086382) (tHpCS), cis-heptachlorostyrene (29086393) (cHpCS), beta,beta-heptachlorostyrene (29082755) (bbHpCS), or octachlorostyrene (29082744) for 96 hours at 21 degrees-C in a specially designed system containing brackish water. Toxicity of the compounds was determined by determining the median lethal concentration (LC50). The compounds were tested for mutagenicity in the Amesalmonella system using strains (TA-98) or (TA-100). Bioaccumulation potential of the compounds was assessed by determining the partition coefficients between octanol and water. The LC5Os to Nitocra were: pentachlorostyrene 0.056 milligrams per liter (mg/l), tHCS was greater than 10mg/l, tHpCS 0.15mg/l, cHpCS O.034mg/l, bbHpCS 0.038mg/l, and octachlorostyrene 0.068mg/l. None of the compounds were mutagenic toward (TA-98) and (TA-100). The logarithm of the partition coefficients (log-P) of the compounds ranged from 6.86 to 7.68, indicating a very high bioaccumulation potential. The authors note that the log-P values of the chlorinated styrenes are comparable to those of other lipophilic compounds with high bioaccumulation potentials, such as DDT and 2,4',5'-trichlorobiphenyl which both have log-Ps of 6.19.