Effect of various dietary xenobiotics on serum total cholesterol and high density lipoprotein cholesterol in rats | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2197761

Reference Type

Journal Article

Title

Effect of various dietary xenobiotics on serum total cholesterol and high density lipoprotein cholesterol in rats

Author(s)

Kato, N; Yoshida, A

Year

1981

Is Peer Reviewed?

Journal

Nutrition Reports International
ISSN: 0029-6635

Volume

Issue

Page Numbers

825-832

Language

English

Web of Science Id

WOS:A1981LQ60600006

Abstract

Effect of feeding xenobiotics on serum cholesterol and high density lipoprotein (HDL)-cholesterol in rats was examined. Dietary addition of 0.05% PCB (polychlorinated biphenyls), 0.3% chloretone, 0.05% DDT, 0.3% BHA (3-tert-butyl-4-methoxyphenol), 0.3% caffeine, 0.2% BHT (2,6-di-tert-butyl-p-cresol) or 0.2% sodium pentobarbital resulted in a significant increase in serum total cholesterol and HDL-cholesterol. A good correlation between serum total cholesterol and HDL-cholesterol was also observed. Dietary PCB, chloretone, caffeine and pentobarbital decreased the ratio of low density lipoprotein and very low density lipoprotein-cholesterol vs. HDL-cholesterol, but dietary BHA and BHT increased the ratio.