The xenobiotics interactions affecting microsomal mixed function oxidase system, serum cholesterol and urinary ascorbic acid | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2199997

Reference Type

Journal Article

Title

The xenobiotics interactions affecting microsomal mixed function oxidase system, serum cholesterol and urinary ascorbic acid

Author(s)

Nagaoka, S; Miyazaki, H; Aoyama, Y; Yoshida, A

Year

1988

Is Peer Reviewed?

Journal

Nutrition Reports International
ISSN: 0029-6635

Volume

Issue

Page Numbers

19-31

Language

English

Web of Science Id

WOS:A1988L629600003

URL

http://://WOS:A1988L629600003
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Abstract

The combined effects of polychlorinated biphenyls (PCB) and DDT on serum and liver lipids, liver and urinary ascorbic acid, liver microsomal mixed function oxidase system were investigated in male Wistar rats. Serum level of cholesterol, liver and urinary ascorbic acid, liver total lipids, liver microsomal aniline hydroxylase activity, aminopyrine N-demethylase activity, cytochrome c reductase activity, cytochrome P-450, b5 content were significantly increased in rats given either DDT or PCB. The combination of PCB and DDT induced essentially additive effects with respect to above-mentioned changes associated with PCB or DDT-feeding.