US EPA

2204047 

Journal Article 

Toxicodynamics of PCB 1254 in the beagle dog and miniature swine 

Couvillion, JL; Earl, FL; Van Loon, EJ 

1974 

29 

1 

104 

English 

http://www.sciencedirect.com/science/journal/0041008X/29/1
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is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974

Abstract #73: Reproductive effects of Aroclor 1254 were studied in the Beagle dog and miniature swine at daily oral doses of 0.25,l and 5 mg/kg in the dog and 1,lO and 30 mg/kg in the pig. An anorectic response was induced in the dog at the 5 mg/kg dose while a higher dose of 30 mg/kg was required for the pig. In both species fetal liver concentrations and fetal abnormalities showed that PCB penetrated the placental barrier. The rate of decay of PCB concentration in blood was measured in the adult Beagle dog. After 3 weeks of conditioning at 10 mg/kg, po, dogs were infused iv with 50 mg/kg Aroclor 1254 as a 10 y0 emulsion. A half-life of 35 hr was obtained with a first-order decay rate. Tissue analysis for PCB in treated animals showed that adipose tissue and liver were major storage sites. 

13th Annual Meeting of the Society of Toxicology 

Washington, DC 

March 10-14, 1974