US EPA

2204627 

Technical Report 

Hepatocellular responses and species variation to organochlorine compounds 

Fulfs, JC 

1976 

PESTAB/77/0396 

Abstr 

6 

2751; 1976 

has other version or edition 2200154 Effects of mirex and chloroquine on PCB-induced hepatic porphyria in the rat

PESTAB. Centrilobular hypertrophy and focal necrosis were both time and dose-related in mice fed 1, 5, 15 and 30 ppm mirex for up to 18 months; minimal centrilobular hypertrophy was found in rats given 30 ppm for 12 months, and there were no changes in monkey livers after 26 months at 20 ppm in the diet. After 7 days, mice given 25 mg/kg Aroclor 1254 had minimal centrilobular hypertrophy, mice given 4.5 mg/kg mirex had extensive centrilobular hypertrophy, and mice given 4.5 mg/kg mirex and 25 mg/kg Aroclor had minimal centrilobular hypertrophy with a centrilobular hyperplasia which distorted the normal liver cord arrangement, as well as large PAS positive, acid phosphatase-active vacuoles containing S.E.R., R.E.R., and mitochondria observed in centrilobular hepatocytes, sinusoids, and bile canaliculi. Porphyrin granules associated with lysosomes were found in centrilobular hepatocytes of mice given 25 mg/kg Aroclor 1221 or 25 mg/kg Aroclor with 1.5 mg/kg mirex; none appeared in a group given only mirex. In the group given both Aroclor and mirex, the porphyrins extended throughout the liver lobule. Application of chloroquine caused total reduction of porphyrin-laden lysosomes. (Author abstract by permission, abridged. Copies of the thesis are available from University Microfilms, Order No. 76-27,414.)