US EPA

2204805 

Journal Article 

Abstract 

Dominant lethal studies in rats of the polychlorinated biphenyls, Aroclor 1242 and 1254 

Green, S; Sauro, FM; Palmer, KA 

1974 

1 

Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 

29 

1 

103 

English 

WOS:A1974T653800078 

is part of a larger document 3378179 Abstracts of papers for the Thirteenth Annual Meeting of the Society of Toxicology, Washington, D.C. March 10–14, 1974

An investigation of the possible mutagenicity of the polychlorinated biphenyls, Aroclors 1242 and 1254, as measured by the induction of dominant lethality, was undertaken. Random bred male and female Osborne-Mendel rats weighing 275-350 and 200-250 g, respectively, were used. The protocol followed the usual dominant lethal procedures. Male animals were dosed (PO) acutely or subacutely (5 days) and subsequently mated to females over the entire spermatogenicycle. Aroclor 1242 was administered as a solution in corn oil at acute dosages of 625,125O and 2500 mg/kg and subacutely at 125 and 250 mg/kg. Aroclor 1254 was administered subacutely as a solution in corn oil at 75, 150 and 300 mg/kg. Additionally, rats of one group were administered Aroclor 1254 at 150 mg/kg subacutely and were starved overnight after the last dosage, prior to the admittance of females. The negative control group received corn oil. The positive control compound triethylenemelamine was administered acutely at 0.5 mg/kg and subacutely at 0.2 mg/kg. The results, except in the case of the positive control, showed random, unrepeatable positive effects that were not related to dose or stage sensitivity. These responses were considered to be due to normal variation. Consequently Aroclors 1242 and 1254 do not appear to be mutagenic as measured by the induction of dominant lethality in the rat. 

Thirteenth Annual Meeting of the Society of Toxicology 

Washington, DC 

March 10-14, 1974