Cytochrome P-4501A activity and mPNA level in the liver and lungs of rats after induction with various xenobiotics | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

2208236

Reference Type

Journal Article

Title

Cytochrome P-4501A activity and mPNA level in the liver and lungs of rats after induction with various xenobiotics

Author(s)

Sharipova, GA; Gulyaeva, LF; Lyakhovich, VV

Year

1998

Is Peer Reviewed?

Journal

Molekulyarnaya Biologiya
ISSN: 0026-8984

Report Number

BIOSIS/99/20420

Volume

MOSCOW

Issue

MOSCOW

Page Numbers

570-573

Language

Russian

Abstract

BIOSIS COPYRIGHT: BIOL ABS. The levels of cytochromes P-4501A1 (CYP1A1) and 1A2 (CYP1A2) mRNA and the respective activities of 7-ethoxyresofurin- and 7-methoxyresofurin-O-dealkylases were compared in rat lungs and liver induced by 3-methylcholathrene, benzo(a)pyrene, beta-naphthoflavone, arochlor 1254, and hexachlorobenzene. Increased level of cytochrome P-4501A (CYP1A1) in the lungs and liver corresponded with intensification 7-ethoxyresofurin-O-dealkylase activity which pointed to transcriptional mechanisms of CYP1A1 ind ction of CYP1A1 and CYP1A2 was regulated by different molecular mechanisms.