Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
2337224
Reference Type
Journal Article
Title
Immunohistochemical analysis of PDK1 expression in breast cancer
Author(s)
Arsenic, R
Year
2014
Is Peer Reviewed?
Yes
Journal
Diagnostic Pathology
ISSN:
1746-1596
Volume
9
Page Numbers
82
Language
English
PMID
24739482
DOI
10.1186/1746-1596-9-82
Web of Science Id
WOS:000335187800001
Abstract
BACKGROUND:
3-phosphoinositide-dependent protein kinase-1 (PDK1) functions downstream of phosphoinositide 3-kinase (PIK3) and activates members of the AGC family of protein kinases that are known to play crucial roles in physiological processes associated with cell metabolism, growth, proliferation and survival. Changes in the expression and activity of PDK1 and several AGC kinases have been linked to human disease, including cancer.
METHODS:
We used immunohistochemical analysis to determine PDK1 expression in 241 tumors from patients with breast cancer in which we had previously analyzed PIK3CA mutation status.
RESULTS:
Moderate or high expression of PDK1 was observed in 213 of the 241 cases (88%). There was no correlation between PIK3CA mutation status and PDK1 overexpression.
CONCLUSION:
Our findings indicate that PDK1 is independently activated in breast cancer and not only as part of the PIK3CA pathway, suggesting that PDK1 plays a specific and distinct role from the canonical PIK3/Akt pathway and promotes oncogenesis independently of AKT. Our data implicate PDK-1 and downstream components of the PDK-1 signaling pathway as promising therapeutic targets for the treatment of breast cancer.
Tags
IRIS
•
Arsenic Hazard ID
PubMed
Excluded
Non Peer Reviewed
2. Lit Search Updates through Oct 2015
PubMed
Initial Filter
Non Peer Reviewed
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
2. Initial Filter
Non peer-reviewed
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity