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Citation
Tags
HERO ID
2345676
Reference Type
Journal Article
Title
[Palmoplantar dermatoses : When should genes be considered?]
Author(s)
Seebode, C; Schiller, S; Emmert, S; Giehl, K
Year
2014
Is Peer Reviewed?
Yes
Journal
Der Hautarzt
ISSN:
0017-8470
EISSN:
1432-1173
Volume
65
Issue
6
Page Numbers
499-512
Language
German
PMID
24898504
DOI
10.1007/s00105-013-2712-0
Web of Science Id
WOS:000337075800006
Abstract
BACKGROUND:
Palmoplantar dermatoses are common. They can be both functionally debilitating and markedly stigmatize the patient because they are so visible. Dermatoses on the hands and feet often go along with palmoplantar hyperkeratosis. Such palmoplantar keratoses (PPK) can be classified into acquired (non-hereditary) and hereditary (monogenetic) PPK.
OBJECTIVES:
A considerable proportion of PPK develop on the grounds of gene defects. As these diseases constitute a heterogeneous group of quite uncommon single entities, the treating physician must know when to entertain the diagnosis of a hereditary PPK and which causative genes should be considered.
METHODS:
We summarize the common causes of acquired and hereditary PPK based on a review of the latest literature.
RESULTS:
The most common causes of acquired PPK are inflammatory dermatoses like psoriasis, lichen planus, or hand and feet eczema. Also irritative-toxic (arsenic poisoning, polycyclic aromatic hydrocarbons) and infectious causes of PPK (human papilloma viruses, syphilis, scabies, tuberculosis, mycoses) are not uncommon. Genetically caused PPK may occur isolated, within syndromes or as a paraneoplastic marker. The clinical/histological classification discerns diffuse, focal, or punctuate forms of PPK with and without epidermolysis. A new classification based on the causative gene defect is starting to replace the traditional clinical classification.
CONCLUSIONS:
Knowledge about the large, but heterogeneous group of hereditary PPK is important to adequately counsel and treat patients and their families.
Keywords
Palmoplantar keratoses; Hyperkeratosis; Gene defect; Causes; Classification
Tags
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Arsenic Hazard ID
PubMed
ToxNet
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WOS
ToxNet
Excluded
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Toxnet Duplicates
2. Lit Search Updates through Oct 2015
PubMed
WOS
ToxNet
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•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
2. Initial Filter
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