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HERO ID
2347513
Reference Type
Journal Article
Title
Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses
Author(s)
Waalkes, MP; Qu, W; Tokar, EJ; Kissling, GE; Dixon, D
Year
2014
Is Peer Reviewed?
Yes
Journal
Archives of Toxicology
ISSN:
0340-5761
EISSN:
1432-0738
Volume
88
Issue
8
Page Numbers
1619-1629
Language
English
PMID
25005685
DOI
10.1007/s00204-014-1305-8
Web of Science Id
WOS:000339898700013
Abstract
In mice, inorganic arsenic in the drinking water in the parts per million range via the dam during in utero life or with whole-life exposure is a multi-site carcinogen in the offspring. However, human arsenic exposure is typically in the parts per billion (ppb) range. Thus, we studied "whole-life" inorganic arsenic carcinogenesis in mice at levels more relevant to humans. Breeder male and female CD1 mice were exposed to 0, 50, 500 or 5,000 ppb arsenic (as sodium arsenite) in the drinking water for 3 weeks prior to breeding, during pregnancy and lactation, and after weaning (at week 3) groups of male and female offspring (initial n = 40) were exposed for up to 2 years. Tumors were assessed in these offspring. Arsenic exposure had no effect on pregnant dam weights or water consumption, litter size, offspring birthweight or weight at weaning compared to control. In male offspring mice, arsenic exposure increased (p < 0.05) bronchiolo-alveolar tumor (adenoma or carcinoma) incidence at 50-ppb group (51 %) and 500-ppb group (54 %), but not at 5,000-ppb group (28 %) compared to control (22 %). These arsenic-induced bronchiolo-alveolar tumors included increased (p < 0.05) carcinoma at 50-ppb group (27 %) compared to controls (8 %). An increase (p < 0.05) in lung adenoma (25 %) in the 50-ppb group compared to control (11 %) occurred in female offspring. Thus, in CD1 mice whole-life arsenic exposure induced lung tumors at human-relevant doses (i.e., 50 and 500 ppb).
Keywords
Arsenic; Carcinogenesis; Mice; Whole-life exposure; Lung cancer
Tags
•
Arsenic Hazard ID
PubMed
ToxNet
Considered New
2. Lit Search Updates through Oct 2015
PubMed
ToxNet
Considered
8. Hazard through Oct 2015
Animal Hazard ID
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
3. Hazard ID Screening
Potentially relevant toxicology studies
Cited in Volume 1
Cited in Volume 2a
•
Arsenic Susceptibility
Life Stages Citation Mapping
5%-10%
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