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Citation
Tags
HERO ID
3070934
Reference Type
Journal Article
Subtype
Supplemental Data
Title
Urinary biomarkers of exposure to 57 xenobiotics and its association with oxidative stress in a population in Jeddah, Saudi Arabia
Author(s)
Asimakopoulos, AG; Xue, J; De Carvalho, BP; Iyer, A; Abualnaja, KO; Yaghmoor, SS; Kumosani, TA; Kannan, K
Year
2016
Is Peer Reviewed?
Yes
Journal
Environmental Research
ISSN:
0013-9351
EISSN:
1096-0953
Publisher
Academic Press Inc.
Location
SAN DIEGO
Volume
150
Page Numbers
573–581
Language
English
PMID
26654562
DOI
10.1016/j.envres.2015.11.029
Web of Science Id
WOS:000382903100068
URL
http://www.sciencedirect.com/science/article/pii/S0013935115301559
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Abstract
Oxidative stress arises from excessive free radicals in the body and is a trigger for numerous diseases, such as cancer and atherosclerosis. Elevated exposure to environmental chemicals can contribute to oxidative stress. The association between exposure to xenobiotics and oxidative stress, however, has rarely been studied. In this study, urinary concentrations of 57 xenobiotics (antimicrobials, parabens, bisphenols, benzophenones, and phthalates metabolites) were determined in a population from Jeddah, Saudi Arabia, to delineate association with the oxidative stress biomarker, 8-hydroxy-2′-deoxyguanosine (8OHDG). We collected 130 urine samples and analyzed for 57 xenobiotics using liquid chromatography-tandem mass spectrometry (LC/MS/MS) methods. The association between unadjusted and creatinine- or specific gravity-adjusted concentrations of xenobiotics and 8OHDG was examined by Pearson correlations and multiple regression analysis. High concentrations of mCPP (a metabolite of di-n-octyl phthalate; DnOP) and mCMHP (a metabolite of diethylhexyl phthalate; DEHP) were found in urine. In addition, the concentrations of bisphenol S (BPS) were higher than those of bisphenol A (BPA). The concentrations of metabolites of DEHP, phthalic acid, BPA, BPS, and methyl-protocatechuic acid were significantly associated with 8OHDG. This is the first biomonitoring study to report exposure of the Saudi population to a wide range of environmental chemicals and provides evidence that environmental chemical exposures contribute to oxidative stress.
Keywords
Phthalates; Phenolics; Parabens; Oxidative stress; Biomonitoring
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Studies with Health Effects Data
Human health effects studies
Litsearch June 2015 - Jan 2016
Pubmed
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Other
Excluded
Source - Dec 2016 Update (Private)
Other
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