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Citation
Tags
HERO ID
32267
Reference Type
Journal Article
Title
The effects of alcohols in vitro on the nervous cell membrane measured by changes in the (Ca2+ / Mg2+) ATPase activity and fluidity of the synaptosomal membrane
Author(s)
Edelfors, S; Ravn-Jonsen, A
Year
1990
Is Peer Reviewed?
1
Journal
Pharmacology & Toxicology
ISSN:
0901-9928
EISSN:
1600-0773
Report Number
NIOSH/00236571
Volume
67
Issue
1
Page Numbers
56-60
Language
English
PMID
2144347
DOI
10.1111/j.1600-0773.1990.tb00782.x
Abstract
The effect of various alkanols on the central nervous system was studied by using rat brain synaptosomal membranes as an in vitro model. The activity of (Ca2+/Mg2+)ATPase and the membrane fluidity were determined. The n-alkanols exhibited an increased molar inhibition of the ATPase activity with an increase in the carbon chain length up to 1-octanol. 1-octanol and 1-decanol caused a biphasic effect on the ATPase activity depending on the alkanol concentration, whereas 1-dodecanol caused a stimulation of the ATPase activity. All alkanols studied caused an increased fluidity of the membrane. Our results indicate that the effect of alkanols on the ATPase activity depends on changes in the border layer between the membrane and the surrounding medium and on a binding of the alkanols to the enzyme molecule. Furthermore, the two-way effect of 1-octanol and 1-decanol and the stimulatory effect of 1-dodecanol indicate that more mechanisms are involved. In addition, the results indicate that changes in the membrane fluidity do not seem to be a prerequisite of the ATPase inhibition.
Keywords
DCN-236996
;
In vitro studies
;
Central nervous system
;
Alcohols
;
Toxic effects
;
Neurotoxic effects
;
Cell biology
;
Bioassays
;
Laboratory animals
;
Chemical properties
Tags
IRIS
•
tert-Amyl ethyl ether (TAEE)
Initial Litsearch 6/2018
From PPRTV
•
n-Butanol
Additional Strategies
•
tert-Butanol
Considered Studies
Electronic Search
•
n-Butanol
Source – January 2013 (private)
Additional strategies - 1/2013
Merged reference set - 1/2013
Previous only - Not found in update search - 1/2013
•
tert-Butanol
Excluded/ Not on Topic
Other Chemical/Non-tert-butanol
•
n-Butanol
Supporting Studies
Mechanistic and genotoxicity studies
PFAS
•
PFAS 150
Literature Search August 2019
PubMed
ToxNet
Not prioritized for screening
11:1 Fluorotelomer alcohol
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