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HERO ID
3350329
Reference Type
Journal Article
Title
Phthalate metabolite levels and menopausal hot flashes in midlife women
Author(s)
Ziv-Gal, A; Gallicchio, L; Chiang, C; Ther, SN; Miller, SR; Zacur, HA; Dills, RL; Flaws, JA
Year
2016
Is Peer Reviewed?
1
Journal
Reproductive Toxicology
ISSN:
0890-6238
EISSN:
1873-1708
Volume
60
Page Numbers
76-81
Language
English
PMID
26867866
DOI
10.1016/j.reprotox.2016.02.001
Web of Science Id
WOS:000376225400009
URL
https://search.proquest.com/docview/1790967171?accountid=171501
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Abstract
During the menopausal transition, a woman's reproductive capacity declines, her hormone milieu changes, and her risk of hot flashes increases. Exposure to phthalates, which can be found in personal care products, can also result in altered reproductive function. Here, we investigated the associations between phthalate metabolite levels and midlife hot flashes. Eligible women (45-54 years of age) provided detailed information on hot flashes history and donated urine samples (n=195). Urinary phthalate metabolite levels were measured by HPLC-MS/MS. A higher total sum of phthalate metabolites commonly found in personal care products was associated with an increased risk of ever experiencing hot flashes (odds ratio (OR)=1.45; 95% confidence interval (CI)=1.07-1.96), hot flashes in the past 30days (OR=1.43; 95%CI=1.04-1.96), and more frequent hot flashes (OR=1.47; 95%CI=1.06-2.05). These data suggest that some phthalate exposures from personal care products are associated with menopausal hot flashes in women.
Keywords
Toxicology Abstracts; Hot flashes; Menopause; Phthalates; Phthalic acid; Metabolites; Data processing; Hormones; X 24350:Industrial Chemicals
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
Litsearch Jan 2016 - July 2016
Pubmed
Studies with Health Effects Data
Human health effects studies
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Other
Included
DEHP
DBP
DiBP
BBP
DEP
Source - Jun 2016 Update (Private)
Other
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