US EPA

39245 

Book/Book Chapter 

Results of long-term carcinogenicity bioassays on tert-amyl-methyl-ether (TAME) and di-isopropyl-ether (DIPE) in rats 

Belpoggi, F; Soffritti, M; Minardi, F; Bua, L; Cattin, E; Maltoni, C 

2002 

Yes 

Annals of the New York Academy of Sciences
ISSN: 0077-8923
EISSN: 1749-6632 

Acad. Sci. 

Ann, NY 

Carcinogenesis bioassays and protecting public health: commemorating the lifework of Cesare Maltoni and colleagues 

982 

70-86 

English 

12562629 

WOS:000180752400004 

Tert-amyl-methyl ether (TAME) was administered by gavage in extra virgin olive oil solution at concentrations of 750, 250, or 0 mg/kg bw to groups of 100 male and 100 female Sprague-Dawley rats 8 weeks old at the start of the experiment. Di-isopropyl ether (DIPE) was administered in the same manner at the doses of 1000, 250, or 0 mg/kg body weight to groups of 100 male and 100 female Sprague-Dawley rats. TAME and DIPE were each delivered in 1-mL solution 4 days a week for 78 weeks. Control animals received 1 mL of extra virgin olive oil without TAME or DIPE. At the end of the treatment period, all animals were kept under observation until spontaneous death. Under these test conditions, TAME and DIPE were found to be potential carcinogenic agents for various organs and tissues. 

Air Pollutants/toxicity; Animals; Biological Assay/methods; Carcinogens/toxicity; Ethers/toxicity; Female; Male; Methyl Ethers/toxicity; Neoplasms, Experimental/chemically induced/classification/pathology; Rats; 0 (Air Pollutants); 0 (Carcinogens); 0 (Ethers); 0 (Methyl Ethers); 108-20-3 (diisopropyl ether); 994-05-8 (tertiary-amyl methyl ether) 

Mehlman, M. A.; Bingham, E.; Landrigan, P. J.; Soffritti, M.; Belpoggi, F.; Melnick, R. L.