Plasmonic Resonance Energy Transfer Enhanced Photodynamic Therapy with Au@SiO2@Cu2O/Perfluorohexane Nanocomposites | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

4239573

Reference Type

Journal Article

Title

Plasmonic Resonance Energy Transfer Enhanced Photodynamic Therapy with Au@SiO2@Cu2O/Perfluorohexane Nanocomposites

Author(s)

Liu, C; Dong, H; Wu, N; Cao, Y; Zhang, X

Year

2018

Is Peer Reviewed?

Journal

ACS Applied Materials & Interfaces
ISSN: 1944-8244
EISSN: 1944-8252

Volume

Issue

Page Numbers

6991-7002

Language

English

PMID

29405051

DOI

10.1021/acsami.8b00112

Web of Science Id

WOS:000426618000024

Abstract

Reactive oxygen species generation efficiency of photosensitizers and hypoxia microenvironment in solid tumor hamper photodynamic therapy (PDT) efficacy. Here, we introduce an efficient inorganic photosensitizer by incorporating plasmonic gold metal nanostructures into Cu2O semiconductors for PDT. By utilizing the plasmon-induced resonance energy transfer (PIRET) process from Au to Cu2O, Au@SiO2@Cu2O (ASC) demonstrates a high singlet oxygen quantum yield of 0.71 under a 670 nm laser irradiation. The ASC is loaded into oxygen self-enriched perfluorohexane (PFH) droplets and coated with liposome (Lip) to form Lip(ASC/PFH) nanocomposites. The achieved Lip(ASC/PFH) shows considerable anticancer efficacy for in vitro cancer cells and in vivo tumor growth. The proposed oxygen self-enriched PIRET-PDT concept has significant implication in PDT design.

Keywords

Copper; Energy Transfer; Fluorocarbons; Nanocomposites; Photochemotherapy; Silicon Dioxide; core−shell structure; perfluorocarbon; photodynamic therapy; plasmonic resonance energy transfer; self-enriched oxygen