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HERO ID
5018050
Reference Type
Journal Article
Title
Maternal urinary 2-hydroxynaphthalene and birth outcomes in Taiyuan, China
Author(s)
Nie, J; Li, J; Cheng, L; Li, Y; Deng, Y; Yan, Z; Duan, L; Niu, Q; Perera, F; Tang, D
Year
2018
Is Peer Reviewed?
1
Journal
Environmental Health
EISSN:
1476-069X
Volume
17
Issue
1
Page Numbers
91
Language
English
PMID
30572877
DOI
10.1186/s12940-018-0436-4
Web of Science Id
WOS:000454122500001
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058882823&doi=10.1186%2fs12940-018-0436-4&partnerID=40&md5=6b9649969b53bf85a4c3cc2b624941a7
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Abstract
BACKGROUND:
Naphthalene is the simplest polycyclic aromatic hydrocarbon (PAH). It is easily emitted into the atmosphere, posing a significant risk to human health. However, limited studies have described the impact of naphthalene exposure on birth outcomes. In this study, we investigated the association between the maternal urinary metabolites of naphthalene, 2-hydroxynaphthalene (2-OH NAP), and birth outcomes.
METHOD:
In the present study, four urinary PAH metabolites were measured in 263 pregnant women during late pregnancy. Multiple linear regression analysis was used to analyze the relationship between the concentrations of 2-OH NAP and birth outcomes, and restricted cubic spline models were further used to examine the shapes of the dose-response association.
RESULT:
General linear models showed that prenatal urinary 2-OH NAP was associated with lower birth weight (BW) (- 4.38% for the high vs. low exposure group of 2-OH NAP; p for trend = 0.049) and higher cephalization index (CI) (4.30% for the high vs. low exposure group of 2-OH NAP; p for trend = 0.038). These associations were linear and significant when 2-OH NAP was modeled as a continuous variable in restricted cubic spline models (P linear = 0.0293 for 2-OH NAP and BW; P linear = 0.0326 for 2-OH NAP and CI). Multiple linear regression data indicated that each 1 ln-unit increase in 2-OH NAP was significantly associated with a 2.09 g/cm increase in the CI. The associations among 2-OH NAP, BW, and CI were also observed in a subset of participants residing close to arterial traffic.
CONCLUSION:
Our data indicated that prenatal exposure to naphthalene had an adverse effect on fetal birth outcomes, especially the brain development index. Reduced exposure to naphthalene may improve newborn health outcomes. In Taiyuan, naphthalene may result from traffic pollution.
Keywords
Environmental Studies; Naphthalene; 2-hydroxynaphthalene; Birth outcomes; Polycyclic aromatic hydrocarbons; Prenatal exposure; Aromatic hydrocarbons; Womens health; Toxicity; Childbirth & labor; Birth weight; Regression analysis; Air pollution; Pregnancy; Metabolites; Exposure; Fetuses; Atmospheric models; Environmental health; Phenols; Health risks; Prenatal experience; Human exposure; Prenatal development; Maternal & child health; Taiyuan China
Tags
IRIS
•
Naphthalene
Database Searches
PubMed
WOS
Toxline
Combined data set
Data set for title/abstract screening
Data set for full text review
Human studies, included
Dermal/Multiple or Unknown Routes of Exposure
Feb 2019 Update
PubMed
Toxline
WOS
•
Phthalates – Targeted Search for Epidemiological Studies
Excluded
Source-March 2019 Update
WOS
•
Naphthalene (2021 Evidence mapping publication)
Database Searches
PubMed
WOS
Toxline
Combined data set
Data set for title/abstract screening
Data set for full text review
Human studies, included
Dermal/Multiple or Unknown Routes of Exposure
Feb 2019 Update
PubMed
Toxline
WOS
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