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61424 
Technical Report 
TSCA Submission 
Screening of priority chemicals for reproductive hazards 
Borriston Laboratories :: Borriston 
1983 
National Institute for Occupational Safety and Health 
FYIOTS04830240IN 
116 
English 
has other version or edition 790471 Screening of priority chemicals for potential reproductive hazard (final report) with attachments and cover sheet (Dec 1983)
is also published as 1481382 Screening of priority chemicals for potential reproductive hazard
is also published as 1798402 final report
has other version or edition 5906928 (final report)
The objective of this work was to determine the effect of nine chemicals on selected reproductive parameters in pregnant white mice. The nine chemicals were diethylene glycol diethyl ether, ethylenethiourea, sodium selenite, ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, triethylene glycol dimethyl ether, p-nitrophenol, dimethyl phthalate, and naphthalene. The study was divided into two parts: (1) Determination of a Maximum Tolerated Dose (MTD) based on adult mortality and weight loss, and (2) A Reproductive Study in which the MTD dose was administered to pregnant SPF CD-1 mice. Both the MTD and reproductive portions of the investigation were completed in blocks of three chemicals each or a total of three blocks for the nine compounds. 
OTS-0000240-0