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6315686 
Journal Article 
Sublethal effects of dermal exposure to poly- and perfluoroalkyl substances on postmetamorphic amphibians 
Abercrombie, SA; de Perre, C; Iacchetta, M; Flynn, RW; SepĂșlveda, MS; Lee, LS; Hoverman, JT 
2021 
Yes 
Environmental Toxicology and Chemistry
ISSN: 0730-7268
EISSN: 1552-8618 
30 
717-726 
English 
Studies of the toxicity of poly- and perfluoroalkyl substances (PFAS) on amphibians, especially after metamorphosis, are limited. We examined effects of dermal PFAS exposure (30 d) on survival and growth of juvenile American toads (Anaxyrus americanus), eastern tiger salamanders (Ambystoma tigrinum), and northern leopard frogs (Rana pipiens). Chemicals included perfluorooctanoic acid, perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and 6:2 fluorotelomer sulfonate (6:2 FTS) at 0, 80, 800, or 8000 ppb on a moss dry weight basis. Exposure to PFAS influenced final snout-vent length (SVL) and scaled mass index (SMI), a measure of relative body condition. Observed effects depended on species and chemical, but not concentration. Anurans exposed to PFOS, PFHxS (frogs only), and 6:2 FTS demonstrated reduced SVL versus controls, whereas salamanders exposed to 6:2 FTS showed increased SVL. Frogs exposed to PFHxS and 6:2 FTS and toads exposed to PFOS had increased SMI compared to controls; salamanders did not demonstrate effects. Concentrations of 6:2 FTS in substrate decreased substantially by 30 d, likely driven by microbial action. Perfluorooctane sulfonate had notable biota-sediment accumulation factors, but was still <1. Although a no-observable-effect concentration could not generally be determined, the lowest-observable-effect concentration was 50 to 120 ppb. Survival was not affected. The present study demonstrates that PFAS bioaccumulation from dermal exposures and sublethal effects are dependent on species, chemical, and focal trait. 
PFAS
• 6:2 Fluorotelomer sulfonic acid
     6:2 Fluorotelomer sulfonic acid
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     Related compounds
          3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctane-1-sulfonate
          6:2 Fluorotelomer sulfonate ammonium salt
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               Other sources
                    ECOTOX
                    PFAS TOX Database
     Potentially relevant supplemental material
          Non-mammalian
• Additional PFAS (formerly XAgency)
• Expanded PFAS SEM (formerly PFAS 430)
     Litsearch Update: November 2021
          PubMed
          Web of Science
     Perfluorooctane
• PFAS 150
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          WOS
     Missing 2021 searches
     Literature Search Update December 2020
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     Literature Search August 2019
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          Web of Science
     Screened Studies
          Supplemental
     6:2 Fluorotelomer sulfonic acid
     Perfluorohexanesulfonic acid
     Perfluorooctane
• PFAS Universe
     Data Source
          Web of Science
          Pubmed
          Screened Studies
               Excluded
                    Exclude (TIAB)
     3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctane-1-sulfonate
     6:2 Fluorotelomer sulfonic acid
     Perfluorohexane
     Perfluorohexanesulfonate
     Perfluorohexanesulfonic acid
     Perfluorooctane
     Perfluorooctanesulfonate
     Perfluorooctanesulfonic acid
     Sodium perfluorohexanesulfonate
     Perfluorooctanoic acid
• PFHxS
     Database searches
          Pubmed
          WOS
          Scopus
          Pelch PFAS SEM
     Supplemental
          TiAb
          Ecotoxicity studies
     Literature Search Update April 2023
          Supplemental
               Ecotoxicity studies
OW - HHRAB
• PFOA (335-67-1) and PFOS (1763-23-1)
     LitSearch: Feb 2019 - May 2020
          PubMed
          WoS
     Literature Search Update (Apr 2019 - Sep 2020)
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          WOS
     LitSearch Update (Sept 2020 - Feb 2022)
          PubMed