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6315697 
Journal Article 
Chronic reproductive toxicity of perfluorooctane sulfonic acid and a simple mixture of perfluorooctane sulfonic acid and perfluorohexane sulfonic acid to northern bobwhite quail (Colinus virginianus) 
Dennis, NM; Karnjanapiboonwong, A; Subbiah, S; Rewerts, JN; Field, JA; Mccarthy, C; Salice, CM; Anderson, TA 
2020 
Yes 
Environmental Toxicology and Chemistry
ISSN: 0730-7268
EISSN: 1552-8618 
etc.4703 
1101-1111 
English 
Per- and poly-fluoroalkyl substances (PFAS) are a broad class of environmentally persistent chemicals that include thousands of potentially toxic synthetic organic molecules. Some PFAS have been shown to cause adverse health effects including decreased total cholesterol, birth weight, and reproductive success in laboratory animals; however, a lack of chronic toxicity data exists for PFAS in avian ecological receptors. The present study reports the chronic toxicity of perfluorooctane sulfonic acid (PFOS) and a mixture of PFOS and perfluorohexane sulfonic acid (PFHxS) to Northern Bobwhite quail (Colinus virginianus) via oral exposure from drinking water. Female weight gain was significantly adversely affected at an average daily intake (ADI) of 3.10x10-3 ± 0.15x10-3 mg PFOS:PFHxS (1.2:1) mixture x kg-1 body weight x day-1 . Successful liberation from shell once pipped was significantly adversely affected at an ADI of 2.45x10-3 ± 0.01x10-3 mg PFOS x kg-1 body weight x day-1 . These values are comparatively much lower than the current dietary avian toxicity reference value (TRV) where birds were exposed via the feed suggesting the need for updated avian TRVs. Relationships between test chemical (PFOS) and test substance (PFOS:PFHxS) showed that PFOS and PFHxS have possible interacting effects in avian receptors and likely differing mechanisms of toxicity depending on chemical co-occurrence and dose. Both the single chemical and mixture exposures produced similar and possibly additive toxicity values. This article is protected by copyright. All rights reserved. 
Index Medicus; Mixture toxicology; Reproductive endpoints; Avian receptors; Stress response; Ecological risk assessment 
• PFHxS
     LitSearch: May 2019 - May 2020
          PubMed
          WoS
• PFOA (335-67-1) and PFOS (1763-23-1)
     LitSearch: Feb 2019 - May 2020
          WoS
          PubMed
     Literature Search Update (Apr 2019 - Sep 2020)
          PubMed
          WOS