Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Download
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
635839
Reference Type
Technical Report
Subtype
EPA Report
Title
Alpha-2u-globulin: Association with chemically induced renal toxicity and neoplasia in the male rat
Author(s)
U.S. Environmental Protection Agency :: U.S. EPA
Year
1991
Publisher
U.S. Environmental Protection Agency, National Center for Environmental Assessment
Location
Washington, DC
Report Number
EPA625391019F. PB92143668
Number of Pages
136
Language
English
URL
https://ntrl.ntis.gov/NTRL/dashboard/searchResults.xhtml?searchQuery=PB92143668
Exit
Abstract
This report of a Technical Panel of the U.S. Environmental Protection Agency (EPA) Risk Assessment Forum describes conditions under which the Forum advises EPA risk assessors against using information on certain renal tubule tumors or nephrotoxicity to assess human risk. Risk assessment approaches generally assume that chemicals producing tumors in laboratory animals are a potential cancer hazard to humans. For most chemicals, including many rodent kidney carcinogens, this extrapolation remains appropriate. The scientific studies reviewed by the Technical Panel indicate, however, that some other chemicals induce accumulation of alpha(sub 2u)-globulin, a low-molecular-weight protein, in the male rat kidney. Female rats and other laboratory mammals administered the same chemicals do not accumulate low-molecular-weight protein in the kidney and they do not develop renal tubule tumors. Since humans appear to be more like other laboratory animals than like the male rat, in this special situation, the male rat is not a good model for assessing human risk.
Keywords
chemically induced; Male; toxicity
NTIS Number
PB92-143668/AS
Tags
IRIS
•
tert-Butanol
Cited in Document
Cited in Public Comment Draft – May 2016
Toxicological Review
Supplemental Materials
•
ETBE
Cited in Document
Not in Lit Search
•
Hexachloroethane (HCE) (Final, 2011)
•
Tetrachloroethylene (Perc) (Final, 2012)
Hazard
Kidney
•
Trichloroethylene (TCE) (Final, 2011)
OPPT REs
•
OPPT_Perchloroethylene (Perc)_A. Summary
Cited in TSCA RE related document
•
OPPT_Perchloroethylene (Perc)_C. Engineering
Total – title/abstract screening
Off topic
•
OPPT_Perchloroethylene (Perc)_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Perchloroethylene (Perc)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Perchloroethylene (Perc)_F. Human Health
Total – title/abstract screening
Off topic
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity