US EPA

661920 

Journal Article 

Abstract 

Prenatal Exposure To Organophosphates And Organochlorines And Performance On The Brazelton Neonatal Behavioral Assessment Scale 

Engel, SM; Berkowitz, GS; Barr, DB; Teitelbaum, S; Siskind, J; Meisel, S; Wolff, MS 

2006 

Yes 

American Journal of Epidemiology
ISSN: 0002-9262
EISSN: 1476-6256 

DART/TER/6001249 

163 

11 Suppl 

S69 

English 

has other version or edition 1061599 Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort
is part of a larger document 3123131 Abstracts 2006 Congress of Epidemiology. a joint meeting of the American College of Epidemiology, American Public Health Association (Epidemiology Section), Society for Epidemiologic Research, Seattle, Washington, June 21-24, 2006

In order to evaluate the effect of in utero pesticide exposure on neurodevelopment, we enrolled a multiethnic cohort of primiparous mothers and their infants who were delivered at Mount Sinai Hospital in New York City between May 1998 and May 2002. Before hospital discharge, the Brazelton Neonatal Behavioral Assessment Scale (BNBAS) was administered to 311 infants. Prenatal maternal urines collected in the third trimester were analyzed for the presence of dialkylphosphate (DAP) metabolites, including three diethylphosphate (DEP) and three dimethylphosphate (DMP) metabolites; and malathion dicarboxylic acid (MDA). A subset of maternal peripheral blood samples were analyzed for the presence of polychlorinated biphenyls (PCBs) and 1,1'-dichloro-2,2'-bis(4-chlorophenyl)ethylene (DDE). For each log unit increase in prenatal urine DEP level, the number of abnormal reflexes elicited increased by 1.38 (95% CI 1.01, 1.89) in an adjusted Poisson model. A similar increase was found for total DAPs. Similarly, MDA levels above the limit of detection (LOD) were associated with a 2.28 increase in the number of abnormal reflexes (95% CI 1.58, 3.27). There was no negative association with PCBs or DDE and any of the BNBAS domains. These results confirm a recently reported association between organophosphate metabolite levels and risk of abnormal reflexes in offspring. However, our results conflict with previous reports of neonatal hypotonicity associated with prenatal PCB exposure. We believe the latter may be explained by the relatively low levels of these contaminants in our population. 

Pregnancy; Infant, Newborn; Infant; Humans; Female; Phosphoric Acid Esters/*TOXICITY/BLOOD; Hydrocarbons, Chlorinated/*TOXICITY/BLOOD; *Prenatal Exposure Delayed Effects/CHEMICALLY; INDUCED/BLOOD/PHYSIOPATHOLOGY; Infant Behavior/*PHYSIOLOGY; Neuropsychological Tests; NO CAS RN 

2nd North American Congress of Epidemiology 

Seattle, WA 

06/21-24/2006