US EPA

683001 

Journal Article 

Effect of phthalic acid esters on drug metabolizing enzymes 

Seth, PK; Agarwal, DK; Agarwal, S 

1981 

Yes 

Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 

26 

6 

764-768 

English 

7260448 

10.1007/BF01622168 

WOS:A1981LV19500009 

http://://WOS:A1981LV19500009
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Abstract: Health hazards of phthalic acid esters, widely used as plasticizers, have been reported recently. In spite of their low order of toxicity, di-(2-ethylhexyl) phthalate (DEHP) and other phthalates have been shown to exert wide variety of subtle toxic effects. Of concern is the property of phthalates to modify the biological responses of some pharmacological agents and other xenobiotics. Earlier studies have reported interaction of DEHP with parathion, pentobarbitone and methaqualone, carbon tetrachloride, and ethanol. The modification of biological response of these chemicals may be related to their altered rates of biotransformation in the presence of DEHP. These observations prompted studies to investigate the effects of DEHP, dimethyl phthalate (DMP), and di-butyl phthalate (DBP) on the activity of aminopyrine-N-demethylase, aniline hydroxylase, and tyrosine aminotransferase in rat liver after single and repeated exposures. ds: hazard determination evised - 2006-11-01 e field[29]: 1,4-Dioxane 

Animals; Dibutyl Phthalate; Diethylhexyl Phthalate; drug effects; Enzymes; enzymology; Esters; Liver; Male; metabolism; Mitochondria,Liver; Mixed Function Oxygenases; Oxidoreductases; Oxygenases; pharmacology; Phthalic Acids; Rats