Perfluoroalkyl substances and cognitive function in older adults: Should we consider non-monotonic dose-responses and chronic kidney disease? | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

6988487

Reference Type

Journal Article

Title

Perfluoroalkyl substances and cognitive function in older adults: Should we consider non-monotonic dose-responses and chronic kidney disease?

Author(s)

Park, SK; Ding, N; Han, D

Year

2020

Is Peer Reviewed?

Yes

Journal

Environmental Research
ISSN: 0013-9351
EISSN: 1096-0953

Volume

192

Page Numbers

110346

Language

English

PMID

33068581

DOI

10.1016/j.envres.2020.110346

Web of Science Id

WOS:000599687100002

URL

https://linkinghub.elsevier.com/retrieve/pii/S0013935120312433
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Abstract

Although potential neurotoxicity of perfluoroalkyl and polyfluoroalkyl substances (PFAS) is suggested, previous epidemiologic studies have reported a 'protective' association between serum PFAS concentration and cognition function. Poor outcome assessment, residual confounding, non-monotonic dose-responses (NMDRs), and the role of reduced kidney function in PFAS excretion may be alternative explanations of these findings.

Keywords

Cognitive function; Confounding; Kidney function; Non-monotonic dose-responses; per- and polyfluoroalkyl substances

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