US EPA

711009 

Journal Article 

Polymorphism of glutathione S-transferase (GST) variants and its effect on distribution of urinary arsenic species in people exposed to low inorganic arsenic in tap water: An exploratory study 

Caceres, DD; Werlinger, F; Orellana, M; Jara, M; Rocha, R; Alvarado, SA; Quiñones, L 

2010 

1 

Archives of Environmental & Occupational Health
ISSN: 1933-8244
EISSN: 2154-4700 

65 

3 

140-147 

English 

20705574 

10.1080/19338240903390354 

WOS:000281425400005 

Glutathione S-tranferases (GST) are multigenic enzymes that have been associated with arsenic metabolism. The objective of this study was to evaluate the relationship between polymorphic variants of GST and urinary concentration of arsenic species in people exposed to low levels of arsenic. A cross-sectional study among 66 nonoccupationally exposed subjects, living in the city of Antofagasta, Chile. Polymorphic variants were analyzed by polymerase chain reaction (PCR) and arsenic species was determined by atomic absorption spectrometry. The effect of GST variants on arsenic concentration was evaluated using univariate and covariate-adjusted regressions. For both GSTT1 and GSTM1 there were no significant differences in detected arsenic relative species between carriers of the active and null polymorphic variants. There was nondefinitive evidence that polymorphic variants of GST play a role in arsenic metabolism in sample of the Chilean subjects studied. 

arsenic; exposure assessment; genetic polymorphism; risk assessment