Life term studies on the effects of arsenic, germanium, tin, and vanadium on spontaneous tumors in mice | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

8376

Reference Type

Journal Article

Title

Life term studies on the effects of arsenic, germanium, tin, and vanadium on spontaneous tumors in mice

Author(s)

Kanisawa, M; Schroeder, HA

Year

1967

Is Peer Reviewed?

Yes

Journal

Cancer Research
ISSN: 0008-5472
EISSN: 1538-7445

Report Number

NIOSH/00129113

Volume

Issue

Page Numbers

1192-1195

Language

English

PMID

4952510

Abstract

Mice fed a diet low in many trace elements and raised in an environment where contamination from extraneous trace elements was controlled were given small amounts (5 Ág/ml) of arsenite, germanate, stannous, or vanadyl ions in drinking water for their life times. Animals receiving arsenite had a significantly decreased incidence of all tumors, and of tumors of the lung, compared to those receiving tin, vanadium, and to controls. Fewer spontaneous tumors were also found in animals given germanium. Significant differences in the incidences of malignant tumors did not appear. None of the elements was carcinogenic in the doses given.

Keywords

DCN-117498; Chemical properties; Animal studies; Tumorigenesis; Mortality rates; Laboratory animals; Laboratory testing; Tumor inhibition; Cancer rates; Metal compounds

Tags

• Arsenic (Inorganic)
     1. Literature
          PubMed
          Toxline, TSCATS, & DART
     4. Adverse Outcome Pathways/Networks Screening
          Excluded/Not relevant
               Title/Abstract screening
• Arsenic MOA
     1. MOA Literature Screening
          MOA Cluster
     3. Excluded
          Other not relevant
               Dragon Screened
• Inorganic Arsenic (7440-38-2) [Final 2025]
     1. Initial Lit Search
          PubMed
          ToxNet
     4. Considered through Oct 2015
     6. Cluster Filter through Oct 2015
• Vanadium Compounds - Oral
     Manual review of existing IRIS and PPRTV assessments
          PPRTV 2009
     Combined data set
          Dataset for title/abstract screening
               Dataset for full text screening
                    Included- Animal studies
     From PPRTV 2008&2009
• Vanadium Inhalation
     Combined Dataset
          Dataset for title/abstract screening
               Supplemental (TIAB)
     Supplemental material
          Non-inhalation route
     Manual review of existing IRIS and PPRTV assessments
          From PPRTV 2008 & 2009